Basement Membrane Proteins, Interstitial Collagens, and Fibronectin in Neurofibroma
نویسندگان
چکیده
منابع مشابه
Perineurial Cells Coexpress Genes Encoding Interstitial Collagens and Basement Membrane Zone Components
Perineurial cell cultures were established from the sciatic nerves of adult Wistar rats. Highly enriched cultures were studied with respect to the production of extracellular matrix components under conditions free from the influence of Schwann cells, axons, or the extracellular matrix of peripheral nerves. Indirect immunofluorescence staining revealed the presence of collagen type IV epitopes,...
متن کاملCross-reactivity of cell-mediated immunity between interstitial (type I) and basement membrane (type IV) collagens
In the present study, we demonstrate delayed-type hypersensitivity (DTH) to homologous type I collagen that cross-reacts with type IV collagen. Mice immunized with native or denatured type I collagens and challenged with these same antigens or native type IV collagen develop a peak DTH response on day 7. Challenge with denatured type IV collagen or collagenase-treated type IV collagen failed to...
متن کاملPerineurial cells coexpress genes encoding interstitial collagens and basement membrane zone components
Perineurial cell cultures were established from the sciatic nerves of adult Wistar rats. Highly enriched cultures were studied with respect to the production of extracellular matrix components under conditions free from the influence of Schwann cells, axons, or the extracellular matrix of peripheral nerves. Indirect immunofluorescence staining revealed the presence of collagen type IV epitopes,...
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Collagen type XV and XVIII are proteoglycans found in the basement membrane zones of endothelial and epithelial cells, and known for their cryptic anti-angiogenic domains named restin and endostatin, respectively. Mutations or deletions of these collagens are associated with eye, muscle and microvessel phenotypes. We now describe a novel role for these collagens, namely a supportive role in leu...
متن کاملDistribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.
Specific antibodies to collagen type IV, laminin, and fibronectin were used to localise these proteins by indirect immunofluorescence in frozen sections of normal and fibrotic liver. In normal livers distinct staining was found in basement membranes of blood and lymph vessels, of bile ducts and ductules and around nerve axons. Positive reactions for type IV collagen and fibronectin were also ob...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1985
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12275341